Premiere of Lifetime's Five, an anthology of five short films exploring the impact of breast cancer on people's lives.

The female-led project put a spotlight on famous women taking the director's chair for each of the five shorts, which air as one movie on Lifetime on Oct. 10 (9 p.m. ET/PT). "I have to say Jennifer and Demi, watching them transform from actors to directors was really exciting to watch," said Tripplehorn, who plays an oncologist in all five shorts. "They are naturals, they should do it more often." Clarkson, who plays a feisty survivor named Mia, also raved about Aniston as a director. "I worked with a little someone named Martin Scorsese and a little someone named Woody Allen and let me tell you, Jennifer holds her own."

Aniston, in a low-cut black vest and slim trousers, literally stopped traffic downtown getting out of her SUV as boyfriend Justin Theroux quickly headed inside the venue. Meanwhile, Clarkson walked the carpet with a diamond-encrusted gold leaf necklace around her neck. "This is from Jennifer Aniston," she said with a smile.

Aniston's favorite part about being back in New York? "The people!" she said, as across the street a topless woman photographed the event. "That is brilliant," laughed Tripplehorn. "That's what it's all about right there. We're dealing with breasts tonight. I love New York!"

Guest list:Five directors Jennifer Aniston, Demi Moore, Patty Jenkins, Penelope Spheeris and Alicia Keys walked the red carpet, alongside stars Patricia Clarkson, Jeanne Tripplehorn and Lyndsy Fonseca.